Plague Inc: Evolved – Xenolith Mega Brutal Guide

Genes aren’t that important tbh, the strategy works without them it’s just a bit slower, but this is what I use:
DNA: ATP Boost (Lets you rush Flash Vitrification)
Outer Space: Doesn’t matter (You won’t be using Meteors)
Network: Doesn’t matter (You won’t be using Crystal Alignment)
Structure: Brittle Lattice (Let’s you shatter more, more shatter = more XNA)
Environment: Xerophile (Use whatever you like tbh)

Saudi Arabia as per usual.

Immediately rush Flash-Vitrification, also grab Lithic Seed.
This will start the Xeno-forming as well as giving you the infectivity and severity you need to generate XNA.

Next take Lithic Fissures to speed up the Xeno-forming, then work your way down the right path grabbing Crust Breach and Ferrous Attraction.
Ferrous Attraction should really kickstart the spread into other countries, generating the XNA you need from infection bubbles.

Next finish off the top right path by grabbing Thermal Siphoning and Tectonic Anchoring. This will really get the Xeno-forming going and boost your XNA production.

Finally max out you humid resistance. This will get you spreading in those stubborn countries that refuse to spread.

Shatter is the meat and potatoes of this strategy.
Take shatter but don’t use it until you have all the upgrades you need (shouldn’t take long with all the XNA you’re generating at this point).
These are the upgrades you need and why:
Crystal Bloom: Essential for infecting those stubborn island countries.
Cascade -> Resonance Cascade: Shatters entire continents at once.
Unstable Construct: Generates massive amounts of XNA from shatter.

Next things next, shatter Saudi Arabia. (This should generate 40-50 XNA at this point)

The important thing now is to just shatter the Americas and Eurasia/Africa whenever you can, make sure at least a few countries have high amounts of infected tho.

Full send down the top right infection path, grabbing Replicating Lattice, Molecular Cleavage, and Harmonic Field. This slows down research as well as increases infectivity, which means more infected get shattered -> more XNA.

Research is probably close to complete at this point (around 80-90%) so you might wanna grab Atomic Reconfiguration 1 and 2.
If research does complete it’s not a huge deal, just buy a Frequency Shift whenever a significant amount of countries have jammers or when the few remaining countries not at 100% Xeno-formed have jammers (Same goes for if they invent prototype jammers before research finishes). This will probably take longer and lower your score however.

Next take Lattice Optimization for faster Xeno-forming, then full send down the bottom right path, grabbing Polymer Assimilation, Grid Siphoning, and Geometric Sprawl. This will overwhelm those pesky wealthy urban countries like the USA.

You’re pretty much done at this point, but if the research is still unfinished you might wanna grab the upgrade that’ll slow it down.
Piezo-Static Charge
Ionic Displacement
Harmonic Disonance -> Void Geometry

YOU WIN! And with 5 biohazards! Maybe, I usually only get 4 tbh but 5 is possible with this strat. You will get the There Can Be Only One achievement tho!